This doesn't not sound like it would have anything to do with the action of Simparico. Benefits: Each tablet provides a full month of protection against fleas and ticks. So now after $90.00 spent on three pills this month, I decide to look up the answers myself. At the same time, Simparica Trio is used to prevent heartworm and lungworm disease (both caused by blood worms that infect the heart and blood vessels supplying the lungs). It's getting better and I decided to just wait and hope when this stuff clears out in 30 days he goes back to normal. She was shaking like she was freezing. After second pill, weve notice he has been a bit down for a couple days. It was a mistake using this and I hope that in 4 weeks when it is out of her system, she will return to normal. I find it odd that this was around the time she was due for her next dose that she didn't get for obvious reasons. He was in excellent health prior to this incident. After being ingested by a dog, sarolaner is distributed throughout the body. I am so sad to read what is happening to some pets. Moxidectin was first approved by the FDA in 1997 for the prevention of heartworm disease in dogs. Today, he wouldn't eat or drink any water. My husband said that he felt like it would just make his coat shiny. Ekko then started having seizures in May,June and July. Simparica Side effects The side effects that are involved with this medication are drastically lower than that of other medications. I am so worried about her! During this period coincidentally I have noticed a change in his behaviour. My 5 year old, healthy Australian Shepherd had a check-up + boosters at the vet on January 24th. Has started to stumble and sleeps 10 to 12 hours at a time. Vet says not to go back to Any brand oral flea/tick meds, so well be using Frontline drops on her shoulders from now on. I only stumbled on the side effects of this drug via a post on a Spinone group. Haven't noticed any other symptoms to him besides the puking, not eating and skittish. They have increased and worsened over the last 3 months. Severity: Severity is mild to moderate to severe Read more. I not any kind of a medical doctor nor am I a vet however I do often research many topics on health related matters both canine and human for decades and then use my common sense to draw logical conclusions or make reasonable guesses. Our guy is having pain and is showing arthritic symptoms. Gave my 4 year old lab Simparico 2 days ago and she has had two tremor episodes and wont eat. I gave my dog simparica trio. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. His skin became itchy and his eyes were too. Vet thinks it may be Addision disease and wants to test for it. I'll be calling them tomorrow. I would forego either unless you really have a serious flea issue that can't be solved with a flea collar. Another possibility would be that the dosage was to high for her (simparica comes in three different dosages). GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. Side effects of Simparica Let us now look at possible side effects when administering Simparica. He licks his lips all the time? They immediately denied they were in the wrong for prescribing because any meds can have side effects but Im convinced this medication is poison. I am going to try stopping the medication for a month to see if things improve. My chihuahua is 18 days since the last seizure episode, she is finally playing again but I'm noticing her shaking her head on the left side and it's very odd. I feel the manufacturer should pay my test bills and meds .. my doc talked me into this regimine of meds and my previous dog did well on sorresto color and heart word med .. any clue on who I contact ? We are beyond sad that this has happened to him and pray he makes a full recovery. We just brought him home from hospital today. I gave 2 of my older Labs a dose of Simparica on a Saturday. Got home 4 hours later and my dog fell down three times and is now seizing mainly her head . That trip cost $400 and the result was he needed Simparica flea treatment. I have always used topical tx. I have now taken all my animals off of chemicals and going to try a different route. It all depends, sadly. My vet recommended Simparica Trio for both my dogs (13 year old healthy Collie mix 7 lb chihuahua mix). How old was your pup? Im so worried Ive lost him forever and hell never recover. I found a warning from the FDA about the potential for neurologic adverse events in dogs and cats when treated with drugs that are in the isoxazoline class. its been 2 weeks .We just had a blood draw done again and they are still high. They drew blood & took a fecal sample . Very "out of it". So sorry! Sarah thanks for your response! This medication is generally well tolerated in most pets. Instead it has become a world of greed. It is better but not gone. Thank u Fox I have good news I did get 2 additional in house potassium test done and they both came back normal. A few months back he started with a morning vomiting always on his empty tummy. We have an appt for a skin scraping. . The FDA considers products in the isoxazoline class to be safe and effective for dogs and cats but is providing this information so that pet owners and veterinarians can take it into consideration when choosing flea and tick products for their pets. Simparica is approved for dogs and puppies weighing more than 2.8 pounds and over 6 months of age. oh I should mention shadow is our 8 yr old dogue de Bordeaux - he has never had a reaction to anything ever before in his life and has never needed a vet so this was not usual at all for him .. My beautiful Golden was switched from her previous Medicine to this one. I will be speaking to vet to switch to something else. I feel so sad for you Camelia. I am very worried I called the vet they said oops sorry they made a mistake. His blood work came back normal but the vet called me to ask if his simparica somehow coincided with time of the seizures. Poor dog prob thinks HE did something wrong. I hope the best for you and dog, I know its a tough time. This is so scary. Simparica Trio also prevents heartworms and keeps hookworms and roundworms from harming your pup. They would clear up after a round of antibiotics but would return the next month. All the swelling went down immediately and the itching went away too. Good appetite and no digestive issues (never had that symptom). I just wish I could find a vet who honestly loves my animals as much as I do. Today March 20 (8 week old) I get a message saying the puppy ate one of these pills that was for the bigger dog she already owned. We spend last night at the Emergency Vet, and all day today at her normal vet. Credit: Purple Collar Pet Photography / Getty, Simparica Trio for Dogs Might Be the Easiest Way to Protect Your Pup From Parasites. And since then has had diarrhea and loose poop. Her Liver enzymes were also through the roof. He will be laying then start shaking all over..Has tremors every 5 minutes for 2 hours now. It comes in a pack of six or 12, but veterinarians typically sell individual doses for growing puppies. I wish I would have seen this site before I gave it my Matty. I am so sorry for your loss. He looked like he was having spasms. Thank you for giving information on what happened to your dog. By overloading chloride into these worms, it affects the electrical activity within their nervous system, causing muscle paralysis and death. I don't recommend anyone risk their pet's life just to be a little easier having a pill to take. the first puppy was still born looks to have died younger .my assumption when I gave lola that pill.she lost 1 puppy .the second baby is doing okay.although the vet said watch for neurological problems and GI problems. I am sorry you are going through this! It wasnt even four hours later all four of my dogs were throwing up, lethargic sick as hell didnt think they were gonna make it three pulled out my little Mr. weenie. Somedays he will have 2 and then he will go for a couple days without having any issues. If anyone wants to write or call to complain to the company I have all the details. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. Nothing. The leaflet inside at least needs to be changed to have the correct information on it. If my dog dies, which does not look too good right now for him, I will stop at nothing to make the company's life miserable. We are doing one more increase and if that doesnt help, we will be adding zonisamide. I started crying carrying his body to my husband . I called the manufacturer (Zoetis) and filed a report, immediately discontinued the tablets and started to detox him. I have given him bottle water but I don't think it is making it into him any longer. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. My vet is aware of this and prescribed simparica. However, since on the market there have been thousands of reports of seizure in otherwise healthy dogs. He seemed okay with his next dose January 1, so we renewed the prescription, and I gave him the February dose too. This excerpt is from the healthline website and in reference to humans "GABA is considered an inhibitory neurotransmitter because it blocks, or inhibits, certain brain signals and decreases activity in your nervous system. I am taking them both off Simparica. He returned to vet, rec'd an allergy injection, first in his life, plus Penicillin x 10 days. Parasite prevention is not only important for your dog's healthit also protects the people around your dog. I notified my vet and Zoetis, the company that makes this drug. Over two weeks later she still can not walk properly. The next morning, she had uncontrollable tremors and could not walk without falling down. I originally wanted to get Nexgard, but for some odd reason, when I had went to my vet to pick it up, instead they gave me this. Im petrified after reading the comments here. There is a possibility it isn't the cause, but it is the only reason I can find and it aligns with the stories of others. What kind of supplements are you giving her? . Poor baby has had vomiting and diarrhoea ever since. Simparica trio is a de-worming medication. These dog training tips will help you get started. But few people read it or think it must be a million to one problem. I had a trainer come in the day of, and he was with me the all day, NOTHING a happened for him to be in pain! Another difference is flavor. Seizures continue and its Monday. I am SO angry with my vet and so mad at myself for not researching first. The Simparica was recommended by the vet. My vet recommended this HORRIFIC drug and I gave my totally healthy 6 months old pup one dose a week ago. That was when I lived in Fort Lauderdale. Gave this to my dogs and now he sleeps all the time and tired and has symptoms now like droopy right side weakness cant blink right eye and drooling like bells palsy. Nothing they can do for her she said. My 8 month old labradoodle has had 2 doses of Simparico Trio. This is terrible. Im a new pet owner and this will sound ignorant Im sure but I had NO IDEA this is how flea meds works and completely trusted my vet who knows my dogs past sensitive history and I was given the drug not even in its package so I could read anything about it but in individual pills. Puppy is having seizures and has aspirated pneumonia. Heres what you need to know about why cats purr and what your cat may be telling you when her motor is running. Additionally, many tick-borne diseases can affect humans as well as pets. Because this ingredient works differently on invertebrates than mammals, however, Simparica for dogs has been proven safe during field trials. Im at the 30 day mark from giving him the symparico and he no longer has pain but they want to continue him on a 4-6 months treatment of steroids as if its meningitis but I dont love the idea because the steroids have side effects too. Very small sample - many deformities, stillborn. Reading all these similar cases cant figure out how the hell this crap is still being prescribed. This happened the same to my dog.. how si going now with your pet? Being in CT where Lyme disease is high it's a relief to have top shelf protection. but wasnt allowed in with him. I just almost had a similar incident with my 16wk cavapoo. Our pup only made it 4 months after her first seizure, but this did seem to help her symptoms toward the end. Random vomitting is no fun either. For all symptoms to be reversed & to return to normal . He had soft poop right after I give him the pill then got worse yellow diarrhea for about a week also vomiting he fine now they changed the medication. he didn't throw up but he doesn't want to go to bed at night and he just paces around the bedroom and sometimes goes under the bed. Two weeks after I made the post above our girl started having seizures and we had to put her down. As I said, the first was a week after taking it, then the 2nd and third seizure happened at day 29. She falls when she runs and when going up and down stairs. This past October he just wasn't the same. Anyway, he prescribed him pain relief for 7 days. The American Heartworm Society recommends year-round heartworm prevention for all dogs in the United States, and the Companion Animal Parasite Council recommends broad-spectrum parasite control to prevent heartworms, intestinal parasites, fleas, and ticks for all dogs in North America. The diarrhea and vomiting went away after a few days but the cough has lingered for over a month now even with treatment. Then she lost control of her legs and couldn't walk or stand. After about 35 days he was back to normal. Kristine, unfortunately my sweet Dolly passed away on October 9th. Hard fast shaking and terrified eyes. Please think these things through before subjecting your pet to internal insecticides. Although vet wanted to treat him for Addison's I decided to wait it out and fortunately it worked out. I looked up side effects for this drug and was horrified to find that the flea med can cause tremors seizures and worse. Hi there, So sorry to hear about your dog. Head down, tail down, will stand in a corner and stare at the wall. No more Simparica for him. All they care about is the money and not the animal. I'm so angry this medication is on the market. Snores like a big dog. Eat grass and vomit. The vet said the simparica didn't cause the disease but it could have been the link that pushed him into the Crisis. He had a serious skin issue a few months back and it was blamed on fleas. My dog is having the same issues. Hopefully there are many other dogs that are unaffected, and just aren't written about here. As I read all the comments I am so alarmed. He is disoriented, his head just hangs and he is lifeless. Contrary to the statement in that same above article "The results are fatal for fleas and ticks but safe for mammals such as your dog." I only researched it after he started not feeling well, just trusted my vet that this was safe. Shes not the carefree setter she was prior to this medication. Just had my 1 yr old goldendoodle to the vet because he has had 3 seizures in the last month. I took him to the energy vet in the morning, he couldnt find any cause for pain, only he yelped a bit on his neck, they had trouble getting him in, he was yanking his neck around as he is afraid of the vet since getting fixed. Never ever again with this med for him. He looked like he was having a seizure. Always confirm storage temperatures by reading the label. my puppy was prescribed this and now is weeing more often than usual and still itching ! Shes now in the Er. But today she isnt eating well, had a bout of diarrhoea and is very tired. He had an MRI and it came out good. Head bobbling and hind legs unable to support her - as if she were really drunk. Update on my Labradoodle who started seizures just a few hours after receiving first dose of Simparica on T-Day 2020 it is March 2021 and my Vet put my dog on Phenobarbital for anti-seizure med. What are the side effects of Simparica Trio for Dogs? Last month she had diarrhea and it lasted 7 days. My 6 year old Chihuahua has been on simparica trio for 4 days . Im so terribly sorry about your puppy. He doesn't seem to be throwing up as much anymore, he did several times throughout the night though. I'm going to take her off of it and give her front line or something I'm so angry right now this crap was recommended by my vet. Them I took him to a vet for check up and to my horror, he has fleas and a tick. Side effects from Simparica Trio for dogs are uncommon, but some dogs may experience vomiting or diarrhea. Can blocking GABA receptors also cause inflammation of spine? He has been using Simparica Trio since it came out several years ago, which eliminates the need for an additional monthly heart guard chewable. First it was a fake guess of Lyme (she's from Texas where Lyme is not) disease diagnosis and $1200 wasted. The ONLY thing that could cause such a huge change in behavior and personality had to be giving him the Simparico Trio the previous week. One common alternative is to give Heartgard for heartworms and intestinal parasites along with Bravecto to prevent fleas and ticks, but there are other choices out there. They want $5k to do a spinal tap and MRI. They gave him IV glucose to raise his Potassium level. Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewablefor protection against: . Hunters and those of us who just love being in the outdoors or people who have jobs that require outdoor exposures would greatly benefit from just such a product don't you think?, YET, there isn't one considered safe for humans. By the following day, she was showing symptoms of marked neurological impairment, similar to a human having suffered a stroke. All said, we are over $8K into vet bills and growing, Given that he had no noted medical issues prior, his vet and the urgent care vet both feel is was likely the Simparico. How long did these symptoms last? Coton de Tulear. He seems to be out of sorts, staring into space, getting freaked out when he can't see me (I thought he was losing his eyesight). I do know that she was a healthy and somewhat energetic 10 year old before the treatment. Has anyone had a dermatitis issue as a result of Simparica? my vet recommended this for both my yorkies. So here we are on the 2nd dose. Just after the 4th dose he started to collapse at his feeding dishes on the floor, next we raised dishes and he did ok for being shaky but continued to decline to the point where he could not use dishes , and now cant eat or drink. Im just hoping my sweet girl is going to be ok. My English Springer Spaniel(Sadie) received her first dose of Simparica Trio at 12 weeks old, with no noticeable side effects. Reading your comments, this drug may be the cause. Zoetis.com.au; Privacy Policy This links to a pdf file; Terms of Use This links to a pdf file Wednesday morning at 5am she awoke with bloody diarrhea and it turned into just blood. He is 5 months old. Charlie took the pill on Monday and could not even walk this morning. 1 is pregnant I told the vet what can I give the pregnant yorkie she said sampirica sold me a 3 month supple for her. Has anyone experienced cardiac issues while under anesthesia on this medication? I will never use this stuff again and will tell anyone I see buying it or using it my story and yours too. I called the vet and she gave me anitdiarrhea medicine. Simparica has a low incidence of seizures but still the FDA made the company include the warning. Some pets fare better with topical solutions instead of chewables. I switched all three of my dogs to simparica trio and ironically my one that is a simi feral h/w+ hound disappeared. I gave simparica trio to my 10-year-old Havanese. Side effects are rare and may include: Neurologic side effects have been seen after using medications in this class of drugs. I dont know whether its a coincidence or not, but 4 days after second dose of Simparica Trio, my dog ended up at an urgent care with blood in his urine. She hasnt had any more seizures but still seems off. Then I gave it to her again the 3rd month and the same thing happened. My dog is 9 yrs old . Its crazy to think they dont recover and can die in a few months. Hi Laura, just wondering what supplements you gave your pup to help and how long it took for her to get back to herself after simparica. I will be discontinuing the medication. She's wobbly on her feet and seems lopsided, although her eyes look ok; she is really lethargic and barely lifting her head. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching . Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). He has been getting groomed since he was 3 months old but we've noticed that he has been getting more anxious with time. ALL oral tick meds are in the same class of drugs, so cannot give anything with that in it. Sorry, cant see you for 4 days. Thank you. Doctor prescribed the salyien with some injunction but all are in vain..my labrador has same issues till datemy vet.not says anything about the side effect of the Simparica..i m now helpless..pls help me what should I do.. please help me to rid over itpls pls ..guide me. And my 1 year old cockapoo has been having regular seizures and her blood work has come back indicative of liver dysfunction. The risk and consequences of tick paralysis are much higher than the risk of side effects. $37.98 with Subscribe & Save discount. Shortly after tablet I introduced sweet potatoes to diet per vet in lieu of potatoes. Training your dog to follow basic commands builds a positive relationship with her and helps ensure her safety. The flavored, chewable tablets were consumed . Daily Paws is part of the Meredith National Digital Network. If you need to get rid of parasites, spot-on (the one by a German company is effective enough) will do the job and do it safely. This crap is poison! They got him to eat a little the next morning and sent him home. I returned that medicine back to the vet and bought Revolution! I gave my 15 year old dog this medicine. It's unique because it kills more types of parasites than any other combination product available to date. The site is secure. This is worth the cost to buy a six-pack of protection. I to also gave my best friend Simparica as recommended by the vet. Im done with this drug! Final Thoughts on Trifexis vs Simparica. Thankfully there have been no other side effects. You ask why they are giving this poison to our furbabies, it's easy. If there are enough reports they may have to pull it off the market until further safety tests can be done. He is not the same puppy prior to two days ago! The vet just gave our 16lb shorkie this on Tuesday and he still has the tremors really bad and very lethargic, Im very worried and concerned. all my dogs were prescribed and my eldest dog has had a strange reaction hives all over his body, panting, restless started same night he took the pill but has had the product on previous occasions with no side effects but this time he had a that reaction,had to administer meticam for the pain and antihistamines for the hives - he is still not right after 4 days and my other dog louie has always suffered from seizures since a pup vet say possible epilepsy - managed without medication at present and I do always try to avoid medication with him as they always make his seizures worse - I am so angry for not researching this further before .. 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